Factor VIII Deficiency (Great Dane)
Body function: Heart & Blood
Hemophilia A is a genetic blood clotting disorder caused by a mutation in the F8 gene on the X chromosome. Due to its X-linked recessive inheritance pattern, it primarily affects males. This condition was first identified in Boxers but can occur in other breeds. Hemophilia A results in impaired blood clotting, leading to excessive bleeding from injuries or even spontaneously.