X-Linked Tremors

X-linked tremors, also known as Shaking Pup Syndrome or hypomyelination, is a severe neurological disorder found in English Springer Spaniels. The condition is caused by a mutation in the PLP1 gene on the X chromosome and is inherited in an X-linked recessive pattern. Males with one copy of the mutation exhibit the full range of symptoms and will pass the mutation to all their female offspring. Females require two copies of the mutation to develop the disease but can carry and transmit the gene if they have only one copy. This disorder affects the normal development of nerve fibers' myelination, leading to significant neurological and motor dysfunction.